MOLECULAR INFORMATION
Molecular information
- Length
- 3 amino acids
- Type
- C-terminal tripeptide of α-MSH · anti-inflammatory, anti-microbial
Amino acid sequence
Lys-Pro-Val KPV (Lys-Pro-Val) is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone (α-MSH). Retains some of the anti-inflammatory activity of the parent hormone without melanocortin-receptor signalling. Marketed grey-market for IBD, oral / mucosal inflammation and skin claims.
Claims vs evidence
- IBD / colitis — preclinical models only
- Oral mucositis — small pilot studies
- Topical anti-inflammatory — limited mechanistic backing
Why we grade it D
The mechanistic case is small and the human evidence is thin. No sponsor is progressing the molecule and no completed RCT supports any of the marketed indications. Sold through grey-market peptide vendors with claims that exceed the data.