MOLECULAR INFORMATION
Molecular information
- Length
- 7 amino acids
- Type
- Synthetic ACTH(4-7) analogue · claimed neuroprotective + nootropic
Amino acid sequence
Met-Glu-His-Phe-Pro-Gly-Pro Semax is a Russian-developed heptapeptide based on a fragment of adrenocorticotropic hormone (ACTH 4-7) extended with a Pro-Gly-Pro stabiliser. Authorised in Russia and Belarus for stroke recovery and ADHD-spectrum indications; not authorised anywhere in the EU, UK or US.
Claims vs evidence
- Stroke recovery — Russian Phase III data, used clinically in origin country
- Cognitive enhancement / ADHD — limited; small Russian trials
- Anxiolytic — claimed; minimal independent support
Why we grade it C
The stroke-recovery indication has the clearest Phase III support, but the trials are single-country and have not been independently replicated in Western populations. Sold widely in grey-market peptide channels in the EU despite restricted-substance status in NL and DE. Promotion above C waits on independent replication.