MOLECULAR INFORMATION
Molecular information
- Length
- 9 amino acids
- Type
- Delta Sleep-Inducing Peptide · 9-AA nonapeptide · putative sleep / stress modulator
Amino acid sequence
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu DSIP is a long-known nonapeptide with persistently inconclusive clinical translation.
Claims vs evidence
- Sleep induction / slow-wave sleep enhancement — mixed trial results, effect size small and variable
- Stress / anxiety modulation — preclinical, weak human evidence
- Pain modulation — preclinical only
Why we grade it D
Despite decades of research, no robust human RCT has demonstrated a clinically meaningful effect for any indication. Modern alternatives with stronger evidence exist for every claimed use.
Frequently asked questions
- What is DSIP?
- A nonapeptide first isolated in the 1970s from rabbit brain during slow-wave sleep. Subsequent research suggested roles in sleep regulation, stress response, and pain modulation, but the picture has remained inconclusive across five decades.
- Does DSIP improve sleep?
- The mechanism remains contested; clinical attempts to use DSIP as a sleep aid have produced mixed and modest results. Modern hypnotics (orexin antagonists, melatonin agonists, GABAergics) all have stronger evidence.
- Is DSIP authorised?
- No — never authorised by any major regulator despite five decades of research. Available only through grey-market peptide channels.