Administration by mouth, with absorption through the gastrointestinal tract.
Therapeutic peptides are typically inactivated by gastric pepsin and intestinal proteases, making oral delivery infeasible for most. Semaglutide tablets (Rybelsus) use the absorption enhancer SNAC to achieve ~1% oral bioavailability.
Compounds where this term is relevant
- Semaglutide · GLP-1 receptor agonist · once-weekly subcutaneous
Related terms
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