MOLECULAR INFORMATION
Molecular information
- Type
- Palmitoyl tripeptide-1 + tetrapeptide-7 · topical matrikine, MMP modulator
Matrixyl 3000 is the trade name for a 2-peptide cosmetic blend — palmitoyl tripeptide-1 (Gly-His-Lys, palmitoylated) and palmitoyl tetrapeptide-7 (Gly-Gln-Pro-Arg) — developed by Sederma and licensed to most major skincare brands. Markets itself as a matrikine signal that downregulates dermal MMPs without retinoid-style irritation.
Use cases
- Topical anti-ageing serums (1–3% concentration is typical)
- Post-procedure barrier formulations
- Cosmetic eye-area treatments
Why we grade it B
Vendor-funded studies demonstrate measurable collagen / hyaluronic-acid uplift at typical formulation concentrations. Independent replication exists but is limited. Listed in CosIng. No therapeutic claims are authorised — the grade reflects cosmetic-class evidence, not dermatological treatment.
Frequently asked questions
- What is Matrixyl 3000?
- A trade-named blend of two cosmetic peptides — palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7 — developed by Sederma. Licensed to most major skincare brands as a topical anti-ageing ingredient.
- Does Matrixyl 3000 really work?
- Vendor-funded studies show measurable collagen and hyaluronic-acid uplift at typical formulation concentrations. Independent replication is limited but exists. The effect is real but modest compared to retinoids.
- Is it safe?
- Yes — listed as a cosmetic ingredient in the EU CosIng database. No therapeutic claims are authorised; the safety record is for cosmetic topical use only.