MOLECULAR INFORMATION
Molecular information
- Length
- 24 amino acids
- Type
- 24-AA mitochondrial-derived peptide · cytoprotective signalling
Amino acid sequence
Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala Humanin is a 24-amino-acid peptide encoded within the mitochondrial 16S rRNA gene. The founding member of the mitochondrial-derived peptide family. Preclinical data shows broad cytoprotective signalling across neuronal, cardiac, metabolic and immune systems. Heavily extrapolated to longevity claims in the grey market.
Claims vs evidence
- Neuroprotection (Alzheimer’s models) — preclinical only
- Cardioprotection — preclinical, some early biomarker data in humans
- Anti-ageing / longevity — extrapolated from circulating-levels observational data, no human RCT
Why we grade it D
Genuinely interesting biology and a growing literature, but the gap between mechanistic plausibility and clinical benefit is unbridged. No human RCT, no sponsor, no authorisation. The peptide is sold through grey channels with claims that the data does not support.